Article
Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling.
The Journal of allergy and clinical immunology - 1 Apr 2017
Ferreira Manuel A R, Jansen Rick, Willemsen Gonneke, Penninx Brenda, Bain Lisa M, Vicente Cristina T, Revez Joana A, Matheson Melanie C, Hui Jennie, Tung Joyce Y, Baltic Svetlana, Le Souëf Peter, Montgomery Grant W, Martin Nicholas G, Robertson Colin F, James Alan, Thompson Philip J, Boomsma Dorret I, Hopper John L, Hinds David A, Werder Rhiannon B, Phipps Simon
Abstract excerpt
BACKGROUND: Hundreds of genetic variants are thought to contribute to variation in asthma risk by modulating gene expression. Methods that increase the power of genome-wide association studies (GWASs) to identify risk-associated variants are needed. OBJECTIVE: We sought to develop a method that aggregates the evidence for association with disease risk across expression quantitative trait loci (eQTLs) of a gene...
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