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Article

KCa3.1 differentially regulates trachea and bronchi epithelial gene expression in a chronic-asthma mouse model

6 Jun 2022

Abstract excerpt

Ion channels are potentially exploitable as pharmacological targets to treat asthma. This study evaluated the role of KCa3.1 channels, encoded by Kcnn4, in regulating the gene expression of mouse airway epithelium and the development of asthma traits. We used the ovalbumin (OVA) challenge as an asthma model in wild-type and Kcnn4−/− mice, performed histological analysis, and measured serum IgE to evaluate asthma...

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Identifiers

PMID: 35658672
DOI: 10.1152/physiolgenomics.00134.2021

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