Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.

Genome medicine - 10 Oct 2021

Soliai Marcus M, Kato Atsushi, Helling Britney A, Stanhope Catherine T, Norton James E, Naughton Katherine A, Klinger Aiko I, Thompson Emma E, Clay Selene M, Kim Soyeon, Celedón Juan C, Gern James E, Jackson Daniel J, Altman Matthew C, Kern Robert C, Tan Bruce K, Schleimer Robert P, Nicolae Dan L, Pinto Jayant M, Ober Carole

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWASs) have identified thousands of variants associated with asthma and other complex diseases. However, the functional effects of most of these variants are unknown. Moreover, GWASs do not provide context-specific information on cell types or environmental factors that affect specific disease risks and outcomes. To address these limitations, we used an upper airway...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma
Share to Bayes Theorem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epithelial Cells

Share to Gene Expression

Share to Genes, erbB-2

Share to Quantitative Trait Loci

Share to Rhinovirus

Source

Open in PubMed Open full text

Identifiers

PMID: 34629083
DOI: 10.1186/s13073-021-00967-y
PMCID: PMC8504130

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.PMID 34629083Read ↗

Multi-omics co-localization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locusSemantic proximity Read ↗

Rhinovirus infection of airway epithelial cells uncovers the non-ciliated subset as a likely driver of genetic susceptibility to childhood-onset asthmaSemantic proximity Read ↗

Rhinovirus infection of airway epithelial cells uncovers the non-ciliated subset as a likely driver of genetic risk to childhood-onset asthma.Semantic proximity Read ↗

Unmasking Pediatric Asthma: Epigenetic Fingerprints and Markers of Respiratory InfectionsSemantic proximity Read ↗

Missing regulatory effects and viral triggers explored for childhood-onset asthma.Semantic proximity Read ↗

Leveraging gene-environment interactions and endotypes for asthma gene discovery.Semantic proximity Read ↗

Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis.Semantic proximity Read ↗

A multi-omics and mediation-based genetic screening approach identifies STX4 as a key link between epigenetic regulation, immune cells, and childhood asthmaSemantic proximity Read ↗

Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associationsSemantic proximity Read ↗

Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in childrenSemantic proximity Read ↗

Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations.Semantic proximity Read ↗

Host genetic variation influences gene expression response to rhinovirus infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.