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Article

A candidate gene identification strategy utilizing mouse to human big-data mining: "3R-tenet" in COPD genetic research.

Respiratory research - 6 Jun 2018

Vishweswaraiah Sangeetha, George Leema, Purushothaman Natarajan, Ganguly Koustav

Abstract excerpt

BACKGROUND: Early life impairments leading to lower lung function by adulthood are considered as risk factors for chronic obstructive pulmonary disease (COPD). Recently, we compared the lung transcriptomic profile between two mouse strains with extreme total lung capacities to identify plausible pulmonary function determining genes using microarray analysis (GSE80078). Advancement of high-throughput techniques...

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Identifiers

PMID: 29871630
DOI: 10.1186/s12931-018-0795-y
PMCID: PMC5989378

Genes

ADAM19
HJURP
KIT
MCRS1
TLR8

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