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Article

Npp1 promotes atherosclerosis in ApoE knockout mice.

Journal of cellular and molecular medicine - 1 Nov 2011

Nitschke Yvonne, Weissen-Plenz Gabriele, Terkeltaub Robert, Rutsch Frank

Abstract excerpt

Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) generates inorganic pyrophosphate (PP(i)), a physiologic inhibitor of hydroxyapatite deposition. In a previous study, we found NPP1 expression to be inversely correlated with the degree of atherosclerotic plaque calcification. Moreover, function-impairing mutations of ENPP1, the gene encoding for NPP1, are associated with severe, artery tunica media...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Smooth, Vascular

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Share to Phosphoric Diester Hydrolases

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Source

Open in PubMed Open full text

Identifiers

PMID: 21477221
DOI: 10.1111/j.1582-4934.2011.01327.x
PMCID: PMC3154990

Genes

ENPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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