Article
Eicosapentaenoic acid prevents arterial calcification in klotho mutant mice.
PloS one - 1 Jan 2017
Nakamura Kazufumi, Miura Daiji, Saito Yukihiro, Yunoki Kei, Koyama Yasushi, Satoh Minoru, Kondo Megumi, Osawa Kazuhiro, Hatipoglu Omer F, Miyoshi Toru, Yoshida Masashi, Morita Hiroshi, Ito Hiroshi
Abstract excerpt
BACKGROUND: The klotho gene was identified as an "aging-suppressor" gene that accelerates arterial calcification when disrupted. Serum and vascular klotho levels are reduced in patients with chronic kidney disease, and the reduced levels are associated with arterial calcification. Intake of eicosapentaenoic acid (EPA), an n-3 fatty acid, reduces the risk of fatal coronary artery disease. However, the effects of...
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