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Uric acid lowering treatment alleviates perivascular carotid collar placement induced neointimal lesions in <i>Uricase</i> knockout mice

2018-07-10

Abstract excerpt

Hyperuricemia (HU) is a cause of gout. Clinical studies show a link between HU and cardiovascular disease. However, the role of soluble serum urate on atherosclerosis development remains elusive. We aimed to use a new HU mouse model ( Uricase/Uox knockout (KO)) to further investigate the relationship between HU and atherosclerosis. Mouse model of induced carotid atherosclerosis was established in the novel sponta...

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Literature Corpus work
9487b441-b641-5e2a-bb71-79c682d5f71b
DOI
10.1101/366096
Open publication

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Uric acid lowering treatment alleviates perivascular carotid collar placement induced neointimal lesions in <i>Uricase</i> knockout miceDOI 10.1101/366096
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