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Article

Osteopontin deficiency attenuates atherosclerosis in female apolipoprotein E-deficient mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2003

Matsui Yutaka, Rittling Susan R, Okamoto Hiroshi, Inobe Manabu, Jia Nan, Shimizu Toshihiro, Akino Masatoshi, Sugawara Takeshi, Morimoto Junko, Kimura Chiemi, Kon Shigeyuki, Denhardt David, Kitabatake Akira, Uede Toshimitsu

Abstract excerpt

OBJECTIVE: Osteopontin (OPN), a noncollagenous adhesive protein, is implicated in atherosclerosis, in which macrophages within atherosclerotic plaques express OPN. However, it is not known whether the elevated OPN expression is a cause or result of atherosclerosis. METHODS AND RESULTS: We generated mice that lacked OPN and crossed them with apolipoprotein (apo) E-deficient mice and analyzed these mice with a...

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Identifiers

PMID: 12730087
DOI: 10.1161/01.ATV.0000074878.29805.D0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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