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Article

Uremia modulates the phenotype of aortic smooth muscle cells.

Atherosclerosis - 1 Feb 2017

Madsen Marie, Aarup Annemarie, Albinsson Sebastian, Hartvigsen Karsten, Sørensen Charlotte M, Turczynska Karolina, Nielsen Lars B, Pedersen Tanja Xenia

Abstract excerpt

BACKGROUND AND AIMS: Chronic kidney disease leads to uremia and markedly accelerates atherosclerosis. Phenotypic modulation of smooth muscle cells (SMCs) in the arterial media plays a key role in accelerating atherogenesis. The aim of this study was to investigate whether uremia per se modulates the phenotype of aortic SMCs in vivo. METHODS: Moderate uremia was induced by 5/6 nephrectomy in apolipoprotein E...

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Source

Identifiers

PMID: 28107707
DOI: 10.1016/j.atherosclerosis.2016.12.022

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