Article
Prevention of accelerated atherosclerosis by AT1 receptor blockade in experimental renal failure.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Mar 2011
Bernardi Stella, Candido Riccardo, Toffoli Barbara, Carretta Renzo, Fabris Bruno
Abstract excerpt
BACKGROUND: The mechanisms of uraemia-induced atherosclerosis have not been fully delineated. The aims of this study were (i) to investigate the extent and the phenotype of atherosclerosis, including the activation of local renin-angiotensin system (RAS), in a mouse model of mild uraemia and (ii) to determine the effects of angiotensin II type1 (AT1) receptor blockade on the uraemic atherosclerosis, clarifying...
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