Article
Detection of lamivudine- or adefovir-resistant hepatitis B virus mutations by a liquid array.
Journal of virological methods - 1 Jul 2011
Liu Hongyan, Mao Richeng, Fan Lili, Xia Jiahui, Li Yiliang, Yin Yongxi, Li Xinyan, Zhao Xu, Guo Hongying, Zhu Haoxiang, Zhang Yongmei, Kang Yaoyue, Zhang Jiming
Abstract excerpt
A novel polymerase chain reaction (PCR)-Luminex assay was developed for rapid, accurate, and high-throughput detection of the most important hepatitis B virus (HBV) variants, including those with reverse transcriptase (RT) domain L180M, M204I/V, A181T/V/S, I233V and N236T mutations associated with resistance to lamivudine (LAM) or adefovir (ADV). Using mixtures of mutant and wild-type HBV, this method was...
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