Article
Performance of LigAmp assay for sensitive detection of drug-resistant hepatitis B virus minor variants in comparison with standard nucleotide sequencing.
Molecular diagnosis & therapy - 1 Dec 2014
Ismail Ashrafali Mohamed, Sachithanandham Jaiprasath, Eapen Chundmannil Eapen, Kannangai Rajesh, Abraham Priya
Abstract excerpt
BACKGROUND AND OBJECTIVES: A virus population often exists as a complex mixture of genetic populations. Antiviral-resistant mutants could be circulating as minority variants in the mixed virus population that are not detected by standard sequencing methods. The role of minor drug-resistant variants and clinical outcome is slowly evolving and there is a need to employ sensitive methods for detection of minority...
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