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Article

Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and <i>nkx2.5</i> function

26 Feb 2013

Abstract excerpt

Second heart field (SHF) progenitors perform essential functions during mammalian cardiogenesis. We recently identified a population of cardiac progenitor cells (CPCs) in zebrafish expressing latent TGFβ-binding protein 3 (ltbp3) that exhibits several defining characteristics of the anterior SHF in mammals. However, ltbp3 transcripts are conspicuously absent in anterior lateral plate mesoderm (ALPM), where SHF...

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PMID: 23444361
DOI: 10.1242/dev.088351

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and <i>nkx2.5</i> functionPMID 23444361Read ↗

Latent TGF-β binding protein 3 identifies a second heart field in zebrafish.Semantic proximity Read ↗

Unique developmental trajectories and genetic regulation of ventricular and outflow tract progenitors in the zebrafish second heart fieldSemantic proximity Read ↗

Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression.Semantic proximity Read ↗

Pbx4 limits heart size and fosters arch artery formation by partitioning second heart field progenitors and restricting proliferationSemantic proximity Read ↗

Fgf8is required for anterior heart field developmentSemantic proximity Read ↗

Continuous addition of progenitors forms the cardiac ventricle in zebrafishSemantic proximity Read ↗

A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac fieldSemantic proximity Read ↗

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.Semantic proximity Read ↗

FGF signaling enforces cardiac chamber identity in the developing ventricleSemantic proximity Read ↗

Cardiac progenitors auto-regulate second heart field cell fate via Wnt secretionSemantic proximity Read ↗

The sinus venosus progenitors separate and diversify from the first and second heart fields early in developmentSemantic proximity Read ↗

Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3.Semantic proximity Read ↗

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