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Pbx4 limits heart size and fosters arch artery formation by partitioning second heart field progenitors and restricting proliferation

24 Feb 2020

Abstract excerpt

ABSTRACT Vertebrate heart development requires the integration of temporally distinct differentiating progenitors. However, few signals are understood that restrict the size of the later-differentiating outflow tract (OFT). We show that improper specification and proliferation of second heart field (SHF) progenitors in zebrafish lazarus (lzr) mutants, which lack the transcription factor Pbx4, produces enlarged...

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PMID: 32094112
DOI: 10.1242/dev.185652

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