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Article

Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3.

Development (Cambridge, England) - 1 Aug 2014

Cambier Linda, Plate Markus, Sucov Henry M, Pashmforoush Mohammad

Abstract excerpt

A complex regulatory network of morphogens and transcription factors is essential for normal cardiac development. Nkx2-5 is among the earliest known markers of cardiac mesoderm that is central to the regulatory pathways mediating second heart field (SHF) development. Here, we have examined the specific requirements for Nkx2-5 in the SHF progenitors. We show that Nkx2-5 potentiates Wnt signaling by regulating the...

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Source

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Identifiers

PMID: 25053429
DOI: 10.1242/dev.103416
PMCID: PMC4197672

Genes

SHF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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