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Article

The sinus venosus progenitors separate and diversify from the first and second heart fields early in development

28 Jan 2010

Abstract excerpt

AIMS: During development, the heart tube grows by differentiation of Isl1(+)/Nkx2-5(+) progenitors to the arterial and venous pole and dorsal mesocardium. However, after the establishment of the heart tube, Tbx18(+) progenitors were proposed to form the Tbx18(+)/Nkx2-5(-) sinus venosus and proepicardium. To elucidate the relationship between these contributions, we investigated the origin of the Tbx18(+) sinus...

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Identifiers

PMID: 20110338
DOI: 10.1093/cvr/cvq033

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