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Article

Non-parallel recombination limits Cre-LoxP-based reporters as precise indicators of conditional genetic manipulation.

Genesis (New York, N.Y. : 2000) - 1 Jun 2013

Liu Jing, Willet Spencer G, Bankaitis Eric D, Xu Yanwen, Wright Chris V E, Gu Guoqiang

Abstract excerpt

Cre/LoxP-mediated recombination allows for conditional gene activation or inactivation. When combined with an independent lineage-tracing reporter allele, this technique traces the lineage of presumptive genetically modified Cre-expressing cells. Several studies have suggested that floxed alleles have differential sensitivities to Cre-mediated recombination, which raises concerns regarding utilization of...

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Identifiers

PMID: 23441020
DOI: 10.1002/dvg.22384
PMCID: PMC3696028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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