Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks.

doi:10.1128/MCB.23.2.733-743.2003

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Article

Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks.

Molecular and cellular biology - 1 Jan 2003

Stark Jeremy M, Jasin Maria

Abstract excerpt

Loss of heterozygosity (LOH) is a common genetic alteration in tumors and often extends several megabases to encompass multiple genetic loci or even whole chromosome arms. Based on marker and karyotype analysis of tumor samples, a significant fraction of LOH events appears to arise from mitotic recombination between homologous chromosomes, reminiscent of recombination during meiosis. As DNA double-strand breaks...

Topics

Alleles
Animals
Cell Line
Chromatids
Chromosomes
Crossing Over, Genetic
DNA Damage
DNA Repair
Genetic Markers
Genotype
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Karyotyping

Loss of Heterozygosity

Mice

Mice, Inbred BALB C

Mitosis

Models, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 12509470
DOI: 10.1128/MCB.23.2.733-743.2003
PMCID: PMC151548

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