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Article

Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks.

Molecular and cellular biology - 1 Jan 2003

Stark Jeremy M, Jasin Maria

Abstract excerpt

Loss of heterozygosity (LOH) is a common genetic alteration in tumors and often extends several megabases to encompass multiple genetic loci or even whole chromosome arms. Based on marker and karyotype analysis of tumor samples, a significant fraction of LOH events appears to arise from mitotic recombination between homologous chromosomes, reminiscent of recombination during meiosis. As DNA double-strand breaks...

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Identifiers

PMID: 12509470
DOI: 10.1128/MCB.23.2.733-743.2003
PMCID: PMC151548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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