Granzyme K drives a newly-intentified pathway of complement activation

Abstract excerpt

Granzymes are a family of serine proteases mainly expressed by CD8 + T cells, natural killer cells, and innate-like lymphocytes 1,2 . Although their major role is thought to be the induction of cell death in virally infected and tumor cells, accumulating evidence suggests some granzymes can regulate inflammation by acting on extracellular substrates 2 . Recently, we found that the majority of tissue CD8 + T ce...

Topics

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• Autoimmune and Inflammatory Disorders Research
• Autophagy in Disease and Therapy
• BH3 Interacting Domain Death Agonist Protein
• Calcium signaling and nucleotide metabolism
• Cell death mechanisms and regulation
• Cytotoxicity, Immunologic
• Granzymes
• Immune Cell Function and Interaction

Identifiers and source

Literature Corpus work

f0f9d7a5-90d0-5124-bdeb-7e256a442bc6

DOI

10.1101/2024.05.22.595315