Article
Meta-analysis identified the TNFA -308G > A promoter polymorphism as a risk factor for disease severity in patients with rheumatoid arthritis.
Arthritis research & therapy - 7 Dec 2012
Toonen Erik J M, Barrera Pilar, Fransen Jaap, de Brouwer Arjan P M, Eijsbouts Agnes M, Miossec Pierre, Marotte Hubert, Scheffer Hans, van Riel Piet L C M, Franke Barbara, Coenen Marieke J H
Abstract excerpt
INTRODUCTION: The goal of this study is to investigate whether the -308G > A promoter polymorphism in the tumor necrosis factor alpha (TNFA) gene is associated with disease severity and radiologic joint damage in a large cohort of patients with rheumatoid arthritis (RA). METHODS: A long-term observational early RA inception cohort (n = 208) with detailed information about disease activity and radiologic damage...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.