Article
Effects of tRNA modification on translational accuracy depend on intrinsic codon-anticodon strength.
Nucleic acids research - 29 Feb 2016
Manickam Nandini, Joshi Kartikeya, Bhatt Monika J, Farabaugh Philip J
Abstract excerpt
Cellular health and growth requires protein synthesis to be both efficient to ensure sufficient production, and accurate to avoid producing defective or unstable proteins. The background of misreading error frequency by individual tRNAs is as low as 2 × 10(-6) per codon but is codon-specific with some error frequencies above 10(-3) per codon. Here we test the effect on error frequency of blocking...
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