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Article

Evolutionary repair reveals an unexpected role of the tRNA modification m1G37 in aminoacylation.

Nucleic acids research - 2 Dec 2021

Clifton Ben E, Fariz Muhammad A, Uechi Gen-Ichiro, Laurino Paola

Abstract excerpt

The tRNA modification m1G37, introduced by the tRNA methyltransferase TrmD, is thought to be essential for growth in bacteria because it suppresses translational frameshift errors at proline codons. However, because bacteria can tolerate high levels of mistranslation, it is unclear why loss of m1G37 is not tolerated. Here, we addressed this question through experimental evolution of trmD mutant strains of...

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Identifiers

PMID: 34761260
DOI: 10.1093/nar/gkab1067
PMCID: PMC8643618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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