Article
G16R single nucleotide polymorphism but not haplotypes of the β(2)-adrenergic receptor gene alters cardiac output in humans.
Clinical science (London, England : 1979) - 1 Aug 2013
Rokamp Kim Z, Staalsoe Jonatan M, Gartmann Martin, Sletgaard Anna, Nordsborg Nicolai B, Secher Niels H, Nielsen Henning B, Olsen Niels V
Abstract excerpt
Variation in genes encoding the β(2)-adrenergic receptor (ADRB2) and angiotensin-converting enzyme (ACE) may influence Q (cardiac output). The 46G>A (G16R) SNP (single nucleotide polymorphism) has been associated with β(2)-mediated vasodilation, but the effect of ADRB2 haplotypes on Q has not been studied. Five SNPs within ADRB2 (46G>A, 79C>G, 491C>T, 523C>A and 1053G>C by a pairwise tagging principle) and the...
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