Article
Interaction between beta2 adrenergic receptor polymorphisms determines the extent of isoproterenol-induced vasodilatation ex vivo.
Pharmacogenetics and genomics - 1 Oct 2007
Khalaila Jawad M, Elami Amir, Caraco Yoseph
Abstract excerpt
OBJECTIVES: Single nucleotide polymorphisms at nucleotides 46, 79 and 491 of the beta2 adrenergic receptor (beta2AR) gene modify its pharmacological properties and may alter the response to agonists. The purpose of this study was to evaluate the role played by beta2AR polymorphisms on isoproterenol-induced relaxation of internal mammary arteries ex vivo. METHODS: Internal mammary leftover segments were collected...
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