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Article

Arginine 16 glycine beta2-adrenoceptor polymorphism and cardiovascular structure and function in patients with heart failure.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography - 1 Mar 2007

Wolk Robert, Snyder Eric M, Somers Virend K, Turner Stephen T, Olson Lyle J, Johnson Bruce D

Abstract excerpt

The beta2/beta1 adrenoceptor ratio increases in congestive heart failure (CHF), making the heart relatively more dependent on inotropic, lusitropic, and chronotropic stimulation by the beta2-adrenergic receptor (ADRB2). In healthy human beings, those who are homozygous for arginine (Arg) at amino acid 16 of the ADRB2 have reduced receptor function when compared with individuals homozygous for glycine (Gly) at...

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Source

Identifiers

PMID: 17336757
DOI: 10.1016/j.echo.2006.08.011

Genes

ADRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Arginine 16 glycine beta2-adrenoceptor polymorphism and cardiovascular structure and function in patients with heart failure.PMID 17336757Read ↗

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