Article
Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure.
Circulation research - 28 Apr 2000
Wagoner L E, Craft L L, Singh B, Suresh D P, Zengel P W, McGuire N, Abraham W T, Chenier T C, Dorn G W, Liggett S B
Abstract excerpt
The beta(2)-adrenergic receptor (beta(2)AR) exists in multiple polymorphic forms with different characteristics. Their relevance to heart failure (HF) physiology is unknown. Cardiopulmonary exercise testing was performed on 232 compensated HF patients with a defined beta(2)AR genotype. Patients with the uncommon Ile164 polymorphism had a lower peak VO(2) (15.0+/-0.9 mL. kg(-1). min(-1)) than did patients with...
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