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Article

The Arg16Gly-β(2)-adrenoceptor single nucleotide polymorphism: exercise capacity and survival in patients with end-stage heart failure.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Oct 2010

Leineweber Kirsten, Frey Ulrich H, Tenderich Gero, Toliat Mohammad Reza, Zittermann Armin, Nürnberg Peter, Körfer Reiner, Siffert Winfried, Heusch Gerd

Abstract excerpt

Heart failure (HF) is characterized by impaired myocardial β-adrenergic signal transduction. Single nucleotide polymorphisms (SNPs) within the β(1)- (Ser49Gly, Arg389Gly) and β(2)-adrenoceptor (Arg16Gly, Gln27Glu, Thr164Ile) have been associated with alterations in adrenoceptor (AR) function sensitivity in vitro and in vivo and possibly contribute to HF progression. The present study evaluated the relation of...

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Identifiers

PMID: 20803192
DOI: 10.1007/s00210-010-0548-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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