Article
Beta2-adrenoceptor gene polymorphisms.
Pharmacogenetics and genomics - 1 May 2005
Brodde Otto-Erich, Leineweber Kirsten
Abstract excerpt
Beta2-adrenoceptors (AR) play an important role in regulation of vascular and bronchial smooth muscle tone; functional beta2-AR, however, also exist in human heart where they can mediate positive inotropic and chronotropic effects. Recent studies have discovered that beta2-AR are polymorphic. The most common single nucleotide polymorphisms (SNPs) are: Arg16Gly, Gln27Glu, Thr164Ile in the coding region, and...
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