Synergy of endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) polymorphisms in atopic dermatitis: Effects on disease prevalence.

doi:10.1016/j.humimm.2020.11.004

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Synergy of endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) polymorphisms in atopic dermatitis: Effects on disease prevalence.

Human immunology - 1 Feb 2021

Niepiekło-Miniewska Wanda, Matusiak Łukasz, Narbutt Joanna, Lesiak Aleksandra, Kuna Piotr, Wiśniewski Andrzej, Piekarska Karolina, Nowak Izabela, Kuśnierczyk Piotr

Abstract excerpt

Endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 trim peptides to a length of 8-10 amino acids optimal for binding by HLA class I molecules. Although these two enzymes may work separately, but they may also form a heterodimer of enhanced trimming efficiency. We have earlier described a role for ERAP1 single nucleotide polymorphism rs26618 and HLA-C*05:01 as risk factors for atopic dermatitis (AD). Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Dermatitis, Atopic

Share to Histocompatibility Antigens Class I

Share to Minor Histocompatibility Antigens

Share to Odds Ratio

Share to Prevalence

Share to Severity of Illness Index

Source

Open in PubMed

Identifiers

PMID: 33309189
DOI: 10.1016/j.humimm.2020.11.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synergy of endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) polymorphisms in atopic dermatitis: Effects on disease prevalence.PMID 33309189Read ↗

The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: insights from genomic-wide association studies.Semantic proximity Read ↗

An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes.Semantic proximity Read ↗

Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: Towards a unifying view.Semantic proximity Read ↗

The Role of Aminopeptidase ERAP1 in Human Pathology—A ReviewSemantic proximity Read ↗

The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective.Semantic proximity Read ↗

Associations of ERAP1 coding variants and domain specific interaction with HLA-C∗06 in the early onset psoriasis patients of India.Semantic proximity Read ↗

Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms and psoriasis susceptibility: A systematic review and meta-analysis.Semantic proximity Read ↗

Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis: Fig. 1Semantic proximity Read ↗

Endoplasmic reticulum aminopeptidases: Biology and pathogenic potential.Semantic proximity Read ↗

ERAP2 protein allotypes show functional diversity in MHC-I antigen presentation in the human populationSemantic proximity Read ↗

The association between endoplasmic reticulum aminopeptidase 2 gene single nucleotide polymorphisms and the risk of psoriasis and psoriatic arthritis in Egyptians.Semantic proximity Read ↗

Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.