Article
Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness.
Cell stem cell - 4 Apr 2013
Kondo Takayuki, Asai Masashi, Tsukita Kayoko, Kutoku Yumiko, Ohsawa Yutaka, Sunada Yoshihide, Imamura Keiko, Egawa Naohiro, Yahata Naoki, Okita Keisuke, Takahashi Kazutoshi, Asaka Isao, Aoi Takashi, Watanabe Akira, Watanabe Kaori, Kadoya Chie, Nakano Rie, Watanabe Dai, Maruyama Kei, Hori Osamu, Hibino Satoshi, Choshi Tominari, Nakahata Tatsutoshi, Hioki Hiroyuki, Kaneko Takeshi, Naitoh Motoko, Yoshikawa Katsuhiro, Yamawaki Satoko, Suzuki Shigehiko, Hata Ryuji, Ueno Shu-Ichi, Seki Tsuneyoshi, Kobayashi Kazuhiro, Toda Tatsushi, Murakami Kazuma, Irie Kazuhiro, Klein William L, Mori Hiroshi, Asada Takashi, Takahashi Ryosuke, Iwata Nobuhisa, Yamanaka Shinya, Inoue Haruhisa
Abstract excerpt
Oligomeric forms of amyloid-β peptide (Aβ) are thought to play a pivotal role in the pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. Here, we generated induced pluripotent stem cells (iPSCs) from familial and sporadic AD patients and differentiated them into neural cells. Aβ oligomers accumulated in iPSC-derived neurons and astrocytes in cells from patients with a familial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.