Article
A commonly carried genetic variant in the delta opioid receptor gene, OPRD1, is associated with smaller regional brain volumes: replication in elderly and young populations.
Human brain mapping - 1 Apr 2014
Roussotte Florence F, Jahanshad Neda, Hibar Derrek P, Sowell Elizabeth R, Kohannim Omid, Barysheva Marina, Hansell Narelle K, McMahon Katie L, de Zubicaray Greig I, Montgomery Grant W, Martin Nicholas G, Wright Margaret J, Toga Arthur W, Jack Clifford R, Weiner Michael W, Thompson Paul M
Abstract excerpt
Delta opioid receptors are implicated in a variety of psychiatric and neurological disorders. These receptors play a key role in the reinforcing properties of drugs of abuse, and polymorphisms in OPRD1 (the gene encoding delta opioid receptors) are associated with drug addiction. Delta opioid receptors are also involved in protecting neurons against hypoxic and ischemic stress. Here, we first examined a large...
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