Differential expression and transcription factor binding associated with genotype at a pharmacogenetic variant in OPRD1.

doi:10.1080/00952990.2021.1954189

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Article

Differential expression and transcription factor binding associated with genotype at a pharmacogenetic variant in OPRD1.

The American journal of drug and alcohol abuse - 3 Sept 2021

Crist Richard C, Arauco-Shapiro Gabriella, Zhang Alexander, Reiner Benjamin C, Berrettini Wade H, Doyle Glenn A

Abstract excerpt

BACKGROUND: The functional mechanism is unknown for many genetic variants associated with substance use disorder phenotypes. Rs678849, an intronic variant in the delta-opioid receptor gene (OPRD1), has been found to predict regional brain volume, addiction risk, and the efficacy of buprenorphine/naloxone in treating opioid use disorder. The variant has also been implicated as an expression quantitative trait...

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PMID: 34407719
DOI: 10.1080/00952990.2021.1954189
PMCID: PMC10311464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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