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Article

OPRD1 SNPs associated with opioid addiction are cis-eQTLs for the phosphatase and actin regulator 4 gene, PHACTR4, a mediator of cytoskeletal dynamics.

Translational psychiatry - 25 May 2021

Levran Orna, Randesi Matthew, Adelson Miriam, Kreek Mary Jeanne

Abstract excerpt

Several OPRD1 intronic variants were associated with opioid addiction (OD) in a population-specific manner. This follow-up study aims to further characterize the OPRD1 haplotype pattern of the risk variants in different populations and apply in silico analysis to identify potential causal variants. A population-specific haplotype pattern was revealed based on six OPRD1 eQTL SNPs and five common haplotypes were...

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Identifiers

PMID: 34031368
DOI: 10.1038/s41398-021-01439-y
PMCID: PMC8144180

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