Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region.

doi:10.1038/jhg.2010.22

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Article

Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region.

Journal of human genetics - 1 May 2010

Zhang Huiping, Gelernter Joel, Gruen Jeffrey R, Kranzler Henry R, Herman Aryeh I, Simen Arthur A

Abstract excerpt

The delta-opioid receptor mediates rewarding effects of many substances of abuse. We reported an increased frequency of the minor G-allele of single-nucleotide polymorphism (SNP) rs569356 (the only variant identified so far in the promoter region of the delta-opioid receptor gene (OPRD1)) in subjects with opioid dependence. In this study, we examined the functional significance of this variant. OPRD1 promoter...

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PMID: 20300121
DOI: 10.1038/jhg.2010.22
PMCID: PMC2876206

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OPRD1

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