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Article

Topological and functional characterization of the ssSPTs, small activating subunits of serine palmitoyltransferase.

The Journal of biological chemistry - 5 Apr 2013

Harmon Jeffrey M, Bacikova Dagmar, Gable Kenneth, Gupta Sita D, Han Gongshe, Sengupta Nivedita, Somashekarappa Niranjanakumari, Dunn Teresa M

Abstract excerpt

The topological and functional organization of the two isoforms of the small subunits of human serine palmitoyltransferase (hssSPTs) that activate the catalytic hLCB1/hLCB2 heterodimer was investigated. A variety of experimental approaches placed the N termini of the ssSPTs in the cytosol, their C termini in the lumen, and showed that they contain a single transmembrane domain. Deletion analysis revealed that the...

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Identifiers

PMID: 23426370
DOI: 10.1074/jbc.M113.451526
PMCID: PMC3617257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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