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Article

Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity.

The Journal of biological chemistry - 17 Mar 2000

Gable K, Slife H, Bacikova D, Monaghan E, Dunn T M

Abstract excerpt

Serine palmitoyltransferase catalyzes the first step of sphingolipid synthesis, condensation of serine and palmitoyl CoA to form the long chain base 3-ketosphinganine. The LCB1/TSC2 and LCB2/TSC1 genes encode homologous proteins of the alpha-oxoamine synthase family required for serine palmitoyltransferase activity. The other alpha-oxoamine synthases are soluble homodimers, but serine palmitoyltransferase is a...

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Source

Identifiers

PMID: 10713067
DOI: 10.1074/jbc.275.11.7597

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity.PMID 10713067Read ↗

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