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Article

Fatty acyl recognition and transfer by an integral membrane S-acyltransferase.

Science (New York, N.Y.) - 12 Jan 2018

Rana Mitra S, Kumar Pramod, Lee Chul-Jin, Verardi Raffaello, Rajashankar Kanagalaghatta R, Banerjee Anirban

Abstract excerpt

DHHC (Asp-His-His-Cys) palmitoyltransferases are eukaryotic integral membrane enzymes that catalyze protein palmitoylation, which is important in a range of physiological processes, including small guanosine triphosphatase (GTPase) signaling, cell adhesion, and neuronal receptor scaffolding. We present crystal structures of two DHHC palmitoyltransferases and a covalent intermediate mimic. The active site resides...

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Identifiers

PMID: 29326245
DOI: 10.1126/science.aao6326
PMCID: PMC6317078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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