Article
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
Nature genetics - 1 Jun 2009
He Chunyan, Kraft Peter, Chen Constance, Buring Julie E, Paré Guillaume, Hankinson Susan E, Chanock Stephen J, Ridker Paul M, Hunter David J, Chasman Daniel I
Abstract excerpt
Age at menarche and age at natural menopause are associated with causes of substantial morbidity and mortality such as breast cancer and cardiovascular disease. We conducted a joint analysis of two genome-wide association studies of these two traits in a total of 17,438 women from the Nurses' Health Study (NHS, N = 2,287) and the Women's Genome Health Study (WGHS, N = 15,151). For age at menarche, we identified...
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