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Article

Loss of function of the mouse Sharpin gene results in Peyer's patch regression.

PloS one - 1 Jan 2013

Seymour Rosemarie, Shirley Bobbi-Jo, Hogenesch Harm, Shultz Leonard D, Sundberg John P

Abstract excerpt

Peyer's patches (PP) are an important component in the immune response against intestinal pathogens. Two independent, spontaneous mutations in the mouse Sharpin gene (Sharpin(cpdm) and Sharpin(cpdm-Dem)) result in the absence of PP and disrupted splenic white pulp in adult mice, although a full complement of lymph nodes is present. Here we report that rudimentary PP begin to develop in Sharpin(cpdm) mice during...

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Source

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Identifiers

PMID: 23424624
DOI: 10.1371/journal.pone.0055224
PMCID: PMC3570409

Genes

SHARPIN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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