SHARPIN is a key regulator of immune and inflammatory responses.

doi:10.1111/j.1582-4934.2012.01574.x

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Article

SHARPIN is a key regulator of immune and inflammatory responses.

Journal of cellular and molecular medicine - 1 Oct 2012

Wang Zhe, Potter Christopher S, Sundberg John P, Hogenesch Harm

Abstract excerpt

Mice with spontaneous mutations in the Sharpin gene develop chronic proliferative dermatitis that is characterized by eosinophilic inflammation of the skin and other organs with increased expression of type 2 cytokines and dysregulated development of lymphoid tissues. The mutant mice share phenotypic features with human hypereosinophilic syndromes. The biological function of SHARPIN and how its absence leads to...

Topics

Animals
Apoptosis
Cytokines
Dermatitis
Gene Expression
Humans
Inflammation
Integrin beta1
Lymphoid Tissue
Models, Animal
Mutation
NF-kappa B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nerve Tissue Proteins

Organogenesis

Phenotype

Signal Transduction

Ubiquitin

Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 22452937
DOI: 10.1111/j.1582-4934.2012.01574.x
PMCID: PMC3402681

Genes

SHARPIN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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SHARPIN is a key regulator of immune and inflammatory responses.PMID 22452937Read ↗

Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice.Semantic proximity Read ↗

Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice.Semantic proximity Read ↗

Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.Semantic proximity Read ↗

Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.Semantic proximity Read ↗

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.Semantic proximity Read ↗

Linear ubiquitination prevents inflammation and regulates immune signalling.Semantic proximity Read ↗

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.Semantic proximity Read ↗

Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell deathSemantic proximity Read ↗

SHARPIN is essential for cytokine production, NF-κB signaling, and induction of Th1 differentiation by dendritic cells.Semantic proximity Read ↗

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.Semantic proximity Read ↗

Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system.Semantic proximity Read ↗

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation.Semantic proximity Read ↗

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