Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice.

doi:10.1371/journal.pone.0186628

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice.

PloS one - 1 Jan 2017

Peuhu Emilia, Salomaa Siiri I, De Franceschi Nicola, Potter Christopher S, Sundberg John P, Pouwels Jeroen

Abstract excerpt

SHARPIN (Shank-Associated RH Domain-Interacting Protein) is a component of the linear ubiquitin chain assembly complex (LUBAC), which enhances TNF-induced NF-κB activity. SHARPIN-deficient (Sharpincpdm/cpdm) mice display multi-organ inflammation and chronic proliferative dermatitis (cpdm) due to TNF-induced keratinocyte apoptosis. In cells, SHARPIN also inhibits integrins independently of LUBAC, but it has...

Topics

Animals
Antibodies, Neutralizing
Apoptosis
Carrier Proteins
Cell Proliferation
Chronic Disease
Dermatitis
Epidermis
Female
Gene Deletion
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inflammation

Integrin beta1

Intracellular Signaling Peptides and Proteins

Keratinocytes

Male

Mice

Mice, Knockout

Source

Open in PubMed Open full text

Identifiers

PMID: 29040328
DOI: 10.1371/journal.pone.0186628
PMCID: PMC5645136

Genes

SHARPIN
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice.PMID 29040328Read ↗

SHARPIN is a key regulator of immune and inflammatory responses.Semantic proximity Read ↗

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.Semantic proximity Read ↗

Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.Semantic proximity Read ↗

Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice.Semantic proximity Read ↗

Linear ubiquitination prevents inflammation and regulates immune signalling.Semantic proximity Read ↗

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.Semantic proximity Read ↗

Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.Semantic proximity Read ↗

Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell deathSemantic proximity Read ↗

SHARPIN is essential for cytokine production, NF-κB signaling, and induction of Th1 differentiation by dendritic cells.Semantic proximity Read ↗

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.Semantic proximity Read ↗

Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system.Semantic proximity Read ↗

Human LUBAC deficiency leads to autoinflammation and immunodeficiency by dysregulation in TNF-mediated cell deathSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.