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Article

Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.

PloS one - 1 Jan 2020

Sundberg John P, Pratt C Herbert, Goodwin Leslie P, Silva Kathleen A, Kennedy Victoria E, Potter Christopher S, Dunham Anisa, Sundberg Beth A, HogenEsch Harm

Abstract excerpt

Spontaneous mutations in the SHANK-associated RH domain interacting protein (Sharpin) resulted in a severe autoinflammatory type of chronic proliferative dermatitis, inflammation in other organs, and lymphoid organ defects. To determine whether cell-type restricted loss of Sharpin causes similar lesions, a conditional null mutant was created. Ubiquitously expressing cre-recombinase recapitulated the phenotype...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 32687504
DOI: 10.1371/journal.pone.0235295
PMCID: PMC7371178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.PMID 32687504Read ↗

Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice.Semantic proximity Read ↗

Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.Semantic proximity Read ↗

SHARPIN is a key regulator of immune and inflammatory responses.Semantic proximity Read ↗

Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice.Semantic proximity Read ↗

SHARPIN is essential for cytokine production, NF-κB signaling, and induction of Th1 differentiation by dendritic cells.Semantic proximity Read ↗

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.Semantic proximity Read ↗

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.Semantic proximity Read ↗

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.Semantic proximity Read ↗

Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression.Semantic proximity Read ↗

Epidermal RelA specifically restricts contact allergen-induced inflammation and apoptosis in skin.Semantic proximity Read ↗

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.Semantic proximity Read ↗

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation.Semantic proximity Read ↗

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