Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.

doi:10.1371/journal.pone.0235295

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.

PloS one - 1 Jan 2020

Sundberg John P, Pratt C Herbert, Goodwin Leslie P, Silva Kathleen A, Kennedy Victoria E, Potter Christopher S, Dunham Anisa, Sundberg Beth A, HogenEsch Harm

Abstract excerpt

Spontaneous mutations in the SHANK-associated RH domain interacting protein (Sharpin) resulted in a severe autoinflammatory type of chronic proliferative dermatitis, inflammation in other organs, and lymphoid organ defects. To determine whether cell-type restricted loss of Sharpin causes similar lesions, a conditional null mutant was created. Ubiquitously expressing cre-recombinase recapitulated the phenotype...

Topics

Animals
Apoptosis
Arthritis
Dermatitis, Atopic
Disease Models, Animal
Gene Expression Regulation
Humans
Immunoglobulin E
Inflammation
Integrases
Interleukin-18

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Keratin-14

Keratinocytes

Mice

NF-kappa B

Nerve Tissue Proteins

Phenotype

S100 Calcium-Binding Protein A4

Source

Open in PubMed Open full text

Identifiers

PMID: 32687504
DOI: 10.1371/journal.pone.0235295
PMCID: PMC7371178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.PMID 32687504Read ↗

Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice.Semantic proximity Read ↗

Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.Semantic proximity Read ↗

SHARPIN is a key regulator of immune and inflammatory responses.Semantic proximity Read ↗

Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice.Semantic proximity Read ↗

SHARPIN is essential for cytokine production, NF-κB signaling, and induction of Th1 differentiation by dendritic cells.Semantic proximity Read ↗

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.Semantic proximity Read ↗

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.Semantic proximity Read ↗

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.Semantic proximity Read ↗

Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression.Semantic proximity Read ↗

Epidermal RelA specifically restricts contact allergen-induced inflammation and apoptosis in skin.Semantic proximity Read ↗

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.Semantic proximity Read ↗

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.