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Article

Novel tumor necrosis factor-knockout mice that lack Peyer's patches.

European journal of immunology - 1 May 2005

Kuprash Dmitry V, Tumanov Alexei V, Liepinsh Dmitry J, Koroleva Ekaterina P, Drutskaya Marina S, Kruglov Andrei A, Shakhov Alexander N, Southon Eileen, Murphy William J, Tessarollo Lino, Grivennikov Sergei I, Nedospasov Sergei A

Abstract excerpt

We generated a novel tumor necrosis factor (TNF) null mutation using Cre-loxP technology. Mice homozygous for this mutation differ from their "conventional" counterparts; in particular, they completely lack Peyer's patches (PP) but retain all lymph nodes. Our analysis of these novel TNF-knockout mice supports the previously disputed notion of the involvement of TNF-TNFR1 signaling in PP organogenesis....

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Identifiers

PMID: 15832287
DOI: 10.1002/eji.200526119

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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