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Article

Splenic lymphopenia in the endothelin receptor B-null mouse: implications for Hirschsprung associated enterocolitis.

Pediatric surgery international - 1 Feb 2011

Cheng Zhi, Wang Xiao, Dhall Deepti, Zhao Lifu, Bresee Catherine, Doherty Terence M, Frykman Philip K

Abstract excerpt

PURPOSE: The aim of the study was to describe and characterize a novel small spleen phenotype with splenic lymphopenia in the Ednrb-null (Ednrb-/-) mouse with aganglionosis known to also develop enterocolitis. METHODS: We compared spleen weight as a percent of body weight from Ednrb+/+, Ednrb+/-, and Ednrb-/- mice to quantify our initial observation. Splenic microarchitecture of Ednrb+/+ and Ednrb-/- mice was...

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Source

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Identifiers

PMID: 21046116
DOI: 10.1007/s00383-010-2787-y
PMCID: PMC3755962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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