Article
Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen.
Development (Cambridge, England) - 1 May 1999
Pabst O, Zweigerdt R, Arnold H H
Abstract excerpt
The homeodomain transcription factor Nkx2-3 is expressed in gut mesenchyme and spleen of embryonic and adult mice. Targeted inactivation of the Nkx2-3 gene results in severe morphological alterations of both organs and early postnatal lethality in the majority of homozygous mutants. Villus formation in the small intestine appears considerably delayed in Nkx2-3(-)/- foetuses due to reduced proliferation of the...
Topics
- Animals
- Animals, Newborn
- Avian Proteins
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Protein 4
- Bone Morphogenetic Proteins
- Cell Division
- Cell Movement
- Gene Expression Regulation
- Gene Targeting
- Homeodomain Proteins
- Intestinal Mucosa
- Intestine, Small