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Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.

Genes and immunity - 1 Jul 2007

Seymour R E, Hasham M G, Cox G A, Shultz L D, Hogenesch H, Roopenian D C, Sundberg J P

Abstract excerpt

Homologues of the SHARPIN (SHANK-associated RH domain-interacting protein) gene have been identified in the human, rat and mouse genomes. SHARPIN and its homologues are expressed in many tissues. SHARPIN protein forms homodimers and associates with SHANK in the post-synaptic density of excitatory neurotransmitters in the brain. SHARPIN is hypothesized to have roles in the crosslinking of SHANK proteins and in...

Topics

Alleles
Amino Acid Sequence
Animals
Dermatitis
Female
Inflammation
Lymphoid Tissue
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nerve Tissue Proteins

Source

Identifiers

PMID: 17538631
DOI: 10.1038/sj.gene.6364403

Genes

SHARPIN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.PMID 17538631Read ↗

Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.Semantic proximity Read ↗

SHARPIN is a key regulator of immune and inflammatory responses.Semantic proximity Read ↗

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.Semantic proximity Read ↗

Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice.Semantic proximity Read ↗

Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice.Semantic proximity Read ↗

SHARPIN is essential for cytokine production, NF-κB signaling, and induction of Th1 differentiation by dendritic cells.Semantic proximity Read ↗

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.Semantic proximity Read ↗

Loss of function of the mouse Sharpin gene results in Peyer's patch regression.Semantic proximity Read ↗

Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell deathSemantic proximity Read ↗

SHARPIN regulates mitochondria-dependent apoptosis in keratinocytes.Semantic proximity Read ↗

Linear ubiquitination prevents inflammation and regulates immune signalling.Semantic proximity Read ↗

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.Semantic proximity Read ↗

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