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Article

The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.

Gastroenterology - 1 Oct 2009

Gregorieff Alex, Stange Daniel E, Kujala Pekka, Begthel Harry, van den Born Maaike, Korving Jeroen, Peters Peter J, Clevers Hans

Abstract excerpt

BACKGROUND & AIMS: Stem cells within the intestinal epithelium generate daughter cells that undergo lineage commitment and maturation through the combined action of the Wnt and Notch signaling cascades. Both pathways, in turn, regulate transcription factor networks that further define differentiation toward either enterocytes or 1 of 3 secretory cell lineages (Paneth, goblet, or enteroendocrine cells). In this...

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Identifiers

PMID: 19549527
DOI: 10.1053/j.gastro.2009.06.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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