Article
An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation.
Blood - 19 May 2011
Nguyen Nhu-Y N, Maxwell Mhairi J, Ooms Lisa M, Davies Elizabeth M, Hilton Adrienne A, Collinge Janelle E, Hilton Douglas J, Kile Benjamin T, Mitchell Christina A, Hibbs Margaret L, Jane Stephen M, Curtis David J
Abstract excerpt
In a recessive ENU mutagenesis screen for embryonic lethality, we identified a mouse pedigree with a missense mutation of SHIP1 (SHIP1(el20)) leading to an amino acid substitution I641T in the inositol-5'-phosphatase domain that represses phosphatidylinositol-3-kinase signaling. Despite detectable expression of functional SHIP1 protein, the phenotype of homozygous SHIP1(el20/el20) mice was more severe than...
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