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Article

Impact of the MTHFR C677T polymorphism on colorectal cancer in a population with low genetic variability.

International journal of colorectal disease - 1 Sept 2013

Delgado-Plasencia Luciano, Medina-Arana Vicente, Bravo-Gutiérrez Alberto, Pérez-Palma Julián, Álvarez-Argüelles Hugo, Salido-Ruiz Eduardo, Fernández-Peralta Antonia M, González-Aguilera Juan J

Abstract excerpt

PURPOSES: Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis by its role in DNA methylation, repair, and synthesis. We analyzed the impact of MTHFR C677T polymorphism in colorectal cancer in a region of the Tenerife Island whose population has a history of genetic isolation and a low genetic variability. This allows analyzing the effects...

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Source

Identifiers

PMID: 23422951
DOI: 10.1007/s00384-013-1644-6

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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