Article
Association between MTHFR polymorphism (C677T) with nonfamilial colorectal cancer.
Oncology research - 1 Jan 2009
Haghighi Mahdi Montazer, Radpour Ramin, Mahmoudi Touraj, Mohebbi Seyed Reza, Vahedi Mohsen, Zali Mohammad Reza
Abstract excerpt
The enzyme 5,10-methylene-tetrahydrofolate reductase (MTHFR) is linked to DNA methylation, synthesis, and repair. C677T is one of the most important polymorphisms in the MTHFR gene. The single nucleotide polymorphism C677T has been found to be associated with decreased enzyme activity and plasma...
Topics
- Aged
- Base Sequence
- Colorectal Neoplasms
- Female
- Folic Acid
- Genotype
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Molecular Sequence Data
- Polymorphism, Genetic